• Users Online: 43164
  • Home
  • Print this page
  • Email this page
CURRENT OPHTHALMOLOGY
Year : 2000  |  Volume : 48  |  Issue : 2  |  Page : 83-92

Limbal stem cell deficiency : Concept, aetiology, clinical presentation, diagnosis and management.


Department of Ophthalmology, Queens Medical Centre, Nottingham, UK

Correspondence Address:
H S Dua
Department of Ophthalmology, Queens Medical Centre, Nottingham, UK

Login to access the Email id

Source of Support: None, Conflict of Interest: None


PMID: 11116520

Rights and PermissionsRights and Permissions

Defects in renewal and repair of ocular surface as a result of limbal stem cell deficiency are now known to cause varying ocular surface morbidity including persistent photophobia, repeated and persistent surface breakdown and overt conjunctivalisation of the cornea. Ocular conditions with abnormalities of ocular surface repair include pterygium, limbal tumours, aniridia, severe scarring following burns, cicatricial pemphigoid and Stevens-Johnson Syndrome, sequelae of mustard gas exposure and Herpes simplex epithelial disease, radiation keratopathy, contact lens induced keratopathy, neuroparalytic keratitis and drug toxicity. Restoring ocular health in these eyes has traditionally been frustrating. An understanding of these intricate cell renewal and maintenance processes has spurred the evolution in recent years of new treatment methods for several blinding diseases of the anterior segment; many more exciting modalities are in the offing. However, there is inadequate awareness among ophthalmologists about the current principles of management of ocular surface disorders. The purpose of this article is to help elucidate the important principles and current treatment methods relevant to ocular surface disorders.


[FULL TEXT] [PDF Not available]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed38574    
    Printed2130    
    Emailed87    
    PDF Downloaded17    
    Comments [Add]    
    Cited by others 42    

Recommend this journal